1α, 25-Dihydroxyvitamin D3 [1α, 25 (OH) 2D3] regulates cellular growth and differentiation.
We show that in keratinocytes, 1α, 25 (OH) 2D3reduces concentrations of the messenger …

Expression of polycystin in mouse metanephros and extra-metanephric tissues. The
presence of messenger RNA for the mouse homologue of the polycystic kidney disease 1 …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease that
affects both adults and children. Renal cysts are the cardinal sign of the disease that also …

Normal renal tissue, ranging from 8 weeks' gestation to full term to adult, was probed with
polyclonal antibodies raised to peptide epitopes within the translated PKD1 gene sequence …

Autosomal dominant polycystic kidney disease (ADPKD), a most common genetic cause of
chronic renal failure, is characterized by the progressive development and enlargement of …

Polycystin-1 is the protein product of the PKD1 gene. Mutations in this gene are responsible
for most cases of polycystic kidney disease, but little is known about how these mutations …

Autosomal dominant polycystic kidney disease (ADPKD) affects millions of individuals
worldwide, is one of the most common, potentially lethal single-gene disorders, is the fourth …

Autosomal-dominant polycystic kidney disease represents one of the most common
monogenetic human disorders. The cloning of the PKD1 and PKD2 genes, which are …

Liver involvement is the most frequent extrarenal organ manifestation seen in autosomal
dominant polycystic kidney disease (ADPKD). Most patients with polycystic liver disease …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially
lethal genetic disorder, accounting for 2%–8% of end-stage renal disease worldwide. While …