Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

Cancer is defined as a large group of diseases that is associated with abnormal cell growth,
uncontrollable cell division, and may tend to impinge on other tissues of the body by different …

Immunotherapy is a promising approach to treating various types of cancers, including
hepatocellular carcinoma (HCC). While single immunotherapy drugs show limited …

Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …

Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …