Simple Summary Melanoma is an aggressive form of skin cancer and the leading cause of
skin cancer-related deaths. Current therapies, including those targeting oncogenic pathways …

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide,
primarily due to its robust desmoplastic stroma and immunosuppressive tumor …

Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Recently,
we demonstrated the overexpression of both DNA methyltransferase 3A (DNMT3A) and 3B …

DNA topoisomerase II (Top2) is essential for all eukaryotic cells in the regulation of DNA
topology through the generation of temporary double-strand breaks. Cancer cells acquire …

Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells
generally referred as cancer stem cells (CSCs) that have been proposed as a strong …

Simple Summary Cellular identity and function depends on the correct and specific
expression of genetic information. Different epigenetic mechanisms including DNA …

DNA and RNA methylation dynamics have been linked to a variety of cellular processes
such as development, differentiation, and the maintenance of genome integrity. The correct …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

Exosomes are extracellular vesicles (EVs) originating from endosomes that play a role in
cellular communication. These vesicles which mimic the parental cells that release them are …