Peripheral T-cell lymphomas (PTCLs) are a group of diseases with a low incidence, high
degree of heterogeneity, and a dismal prognosis in most cases. Because of the low …

Drug combination therapy is generally more effective than monotherapy in the field of cancer
treatment. However, screening for effective synergistic combinations from a wide range of …

The epidermis is the body's first line of protection against dehydration and pathogens,
continually regenerating the outermost protective skin layers throughout life. During both …

PURPOSE The Bromodomain and Extra-Terminal (BET) domain proteins facilitate the
development of many human cancers via epigenetic regulation. BET inhibitors may be …

Targeted therapies, including small molecule inhibitors directed against aberrant kinase
signaling and chromatin regulators, are emerging treatment options for high-grade gliomas …

Lysine-specific histone demethylase 1 (LSD-1) is an epigenetic enzyme that oxidatively
cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 and is highly …

Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain
tumors, pediatric brain tumors are classified based on histopathological evaluations …

There is a consensus that epigenetic alterations play a key role in cancer initiation and its
biology. Studies evaluating the modification in the DNA methylation and chromatin …

Gastric cancer (GC) remains one of the deadliest malignancies worldwide, demanding new
targets to improve its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are …

In the past decade, significant advances in molecular research have provided a deeper
understanding of the intricate regulatory mechanisms involved in carcinogenesis …