Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

Functional interpretation of candidate gene lists is an essential task in modern biomedical
research. Here, we present the 2011 update of g: Profiler (http://biit. cs. ut. ee/gprofiler/), a …

Experimental techniques that survey an entire genome demand flexible, highly interactive
visualization tools that can display new data alongside foundation datasets, such as …

Background DNA methylation has been recognized as a key mechanism in cell
differentiation. Various studies have compared tissues to characterize epigenetically …

Background DNA methylation plays an important role in regulating gene expression during
many biological processes. However, the mechanism of DNA-methylation-dependent gene …

To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …

Cell‐selective glucocorticoid receptor (GR) binding to distal regulatory elements is
associated with cell type‐specific regions of locally accessible chromatin. These regions can …

The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …

The proper location and timing of Dnmt1 activation are essential for DNA methylation
maintenance. We demonstrate here that Dnmt1 utilizes two-mono-ubiquitylated histone H3 …