Ever‐growing research efforts are demonstrating the potential of medicinal plants and their
phytochemicals to prevent and manage obesity, either individually or synergistically …

In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9
(H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced …

The DNA of most vertebrates is depleted in CpG dinucleotide: a C followed by a G in the 5′
to 3′ direction. CpGs are the target for DNA methylation, a chemical modification of …

The study on DNA methylation pattern in different human tissues attracts increasing interest
nowadays, but a systematic analysis of CpG island methylation pattern between both …

DNA methylation plays critical roles in transcriptional regulation and chromatin remodeling.
Differentially methylated regions (DMRs) have important implications for development, aging …

Epigenetic mechanisms may underlie the progression of diabetic kidney disease. Because
the kidney is a heterogeneous organ with different cell types, we investigated DNA …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

Genes constitute only a small proportion of the mammalian genome, the majority of which is
composed of non-genic repetitive elements including interspersed repeats and satellites. A …

More than 20% of adults worldwide experience different types of chronic pain, which are
frequently associated with several comorbidities and a decrease in quality of life. Several …

Atherosclerosis (AS) is a chronic inflammatory disease accompanied by complex
pathological changes, such as endothelial dysfunction, foam cell formation, and vascular …