The role of human DNA methylation has been extensively studied in genomic imprinting, X-
inactivation, and disease. However, studies of tissue-specific methylation remain limited. In …

Six1 belongs to the Six gene family that includes six members in mammals (from Six1 to
Six6). It has been demonstrated that Six1 homeodomain transcription factor is implicated in …

ABSTRACT DNA methylation functions as cellular memory beyond generations of cells and
is involved in many biological processes. Because of its relatively stable nature compared …

The aim of this study was to use a mouse model to gain an understanding of the safety of
reproduction between humans conceived through assisted reproductive technology (ART) …

Current restriction enzyme based reduced representation methylation analyses aim for
limited, but unbiased, methylome coverage. As the current best estimate suggests that only …

Background Tissues and their component cells have unique DNA methylation profiles
comprising DNA methylation patterns of tissue-dependent and differentially methylated …

We report the quantitative analysis of 5-methylcytosine, a representative epigenetic
modification in genomic DNA, with an enzyme-linked immunosorbent assay (ELISA). We …

The Gsg2 (Haspin) gene encodes a serine/threonine protein kinase and is predominantly
expressed in haploid germ cells. In proliferating somatic cells, Gsg2 is shown to be …

Orexin neurons regulate critical brain activities for controlling sleep, eating, emotions, and
metabolism, and impaired orexin neuron function results in several neurologic disorders …

Background: Epigenetic silencing of tumor suppressor genes plays important role in acute
myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK …