The Gsg2 (Haspin) gene encodes a serine/threonine protein kinase and is predominantly
expressed in haploid germ cells. In proliferating somatic cells, Gsg2 is shown to be …

Breast cancer (BC) is the commonest cancer in women worldwide with a widely variable
incidence between countries and regions. BC is either familial or sporadic. Mutations in …

The regulation of transcription and genome stability by epigenetic systems are crucial for the
proper development of mammalian embryos. Chemicals that disturb epigenetic systems are …

Background: Epigenetic silencing of tumor suppressor genes plays important role in acute
myeloid leukemia (AML). Recently, SPRED1, a negative regulator of the RAS MAPK …

Background: Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease
characterized by multifocal bile duct strictures. To date, underlying molecular mechanisms of …

Introduction: Differentially methylated regions (DMRs), including tissue-specific DMRs and
disease-specific DMRs, can be used in revealing the mechanisms of gene regulation and …

Background Genome-wide DNA methylation at a single nucleotide resolution in different
primary cells of the mammalian genome helps to determine the characteristics and functions …

DNA methylation at the 5-position of cytosine bases (5-methylcytosine, 5mC) in genomic
DNA is representative epigenetic modification and is involved in many cellular processes …

Epigenetic systems play crucial roles in the differentiation of a mammalian fertilized egg into
hundreds of cell types exhibiting distinct phenotypes, using a set of DNA molecules …

В обзоре критически анализируются современные данные относительно участия
эпигенетических механизмов в этиологии и предрасположенности к комплексным …