Abstract Purpose Breast Cancer is one of the leading causes of cancer deaths among
women worldwide. The role of epigenetics as a distinct mechanism to alter gene expression …

Cytosine methylation at CpG dinucleotides is an epigenetic mechanism that affects the gene
expression profiles responsible for the functional differences in various cells and tissues …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Background: The orexins (hypocretins) are neuropeptides with an origin in the lateral
hypothalamus. They have been found to be crucial within the context of drug craving …

Changes in DNA methylation during aging have implications for various age-related
diseases. While the deleterious effects of age-dependent methylation changes after …

Spermatogenesis is a highly orchestrated developmental process by which spermatogonia
develop into mature spermatozoa. This process involves many testis‐or male germ cell …

Uterine leiomyoma is the most common benign tumor in women. Although responsible gene
mutations have not been found in leiomyomas, they represent a progressive disease with …

Fuelled by new sequencing technologies, epigenome mapping projects are revealing
epigenomic variation at all levels of biological complexity, from species to cells …

DNA methylation has been mostly studied in circulating blood cells. Although being readily
accessible, metabolically active tissues such as adipose tissue would be more informative …

Background Mitochondria are semi-autonomous, semi-self-replicating organelles harboring
their own DNA (mitochondrial DNA, mtDNA), and their dysregulation is involved in the …