[HTML][HTML] A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis

T Sawicki, M Ruszkowska, A Danielewicz… - Cancers, 2021 - mdpi.com
Simple Summary According to the available data, colorectal cancer (CRC) is one of the most
common malignant neoplasms. Depending on the location, type of cancer or gender, it is …

Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

[HTML][HTML] Circulating cell-free DNA for cancer early detection

Q Gao, Q Zeng, Z Wang, C Li, Y Xu, P Cui, X Zhu, H Lu… - The Innovation, 2022 - cell.com
Effective screening modalities are currently available for only a small subset of cancers, and
they generally have suboptimal performance with complicated procedures. Therefore, there …

[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer

D Müller, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer

WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

[HTML][HTML] DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Advances in tests for colorectal cancer screening and diagnosis

SCH Chan, JQ Liang - Expert review of molecular diagnostics, 2022 - Taylor & Francis
Introduction Colorectal cancer (CRC) is the second leading cause of cancer-related deaths
globally. Nonetheless, with early detection of CRC or its precancerous lesions, mortality, and …

[HTML][HTML] Colorectal cancer detected by liquid biopsy 2 years prior to clinical diagnosis in the HUNT study

SS Brenne, PH Madsen, IS Pedersen, K Hveem… - British Journal of …, 2023 - nature.com
Background Colorectal cancer (CRC) is often diagnosed in advanced stages. Circulating
tumour DNA (ctDNA) has been proposed as an early diagnostic biomarker. However, as a …

DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

N Fatemi, S Tierling, HA Es, M Varkiani… - … journal of cancer, 2022 - Wiley Online Library
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

[HTML][HTML] Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA

YD Han, TJ Oh, TH Chung, HW Jang, YN Kim, S An… - Clinical …, 2019 - Springer
Background Colorectal cancer (CRC) screening can effectively reduce disease-related
mortality by detecting CRC at earlier stages. We have previously demonstrated that the …