[HTML][HTML] Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review
Early life stress (ELS) is a known risk factor for suffering psychopathology in adulthood. The
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
hypothalamic–pituitary–adrenal (HPA) axis has been described to be deregulated in both …
Epigenetics in depression and gut-brain axis: A molecular crosstalk
N Begum, A Mandhare, KP Tryphena… - Frontiers in Aging …, 2022 - frontiersin.org
Gut-brain axis is a dynamic, complex, and bidirectional communication network between the
gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …
gut and brain. Changes in the microbiota-gut-brain axis are responsible for developing …
Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes
Brain cells are continuously exposed to corticosteroid hormones, although the levels vary
(eg, after stress). Corticosteroids alter neural activity via two receptor types …
(eg, after stress). Corticosteroids alter neural activity via two receptor types …
DNA methylation: conducting the orchestra from exposure to phenotype?
FAD Leenen, CP Muller, JD Turner - Clinical epigenetics, 2016 - Springer
Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …
is considered to be one of the principal interfaces between the genome and our …
Cortisol and depression: three questions for psychiatry
J Herbert - Psychological medicine, 2013 - cambridge.org
BackgroundCortisol plays a multifaceted role in major depression disorder (MDD). Diurnal
rhythms are disturbed, there is increased resistance to the feedback action of …
rhythms are disturbed, there is increased resistance to the feedback action of …
Differential glucocorticoid receptor exon 1B, 1C, and 1H expression and methylation in suicide completers with a history of childhood abuse
BACKGROUND: Childhood abuse alters hypothalamic-pituitary-adrenal (HPA) function and
increases the risk of suicide. Hippocampal glucocorticoid receptor (GR) activation regulates …
increases the risk of suicide. Hippocampal glucocorticoid receptor (GR) activation regulates …
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Stress activates a complex network of hormones known as the hypothalamic–pituitary–
adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric …
adrenal (HPA) axis. The HPA axis is dysregulated in chronic stress and psychiatric …
Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans
Parental care influences development across mammals. In humans such influences include
effects on phenotypes, such as stress reactivity, which determine individual differences in …
effects on phenotypes, such as stress reactivity, which determine individual differences in …
Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development
MA Argentieri, S Nagarajan, B Seddighzadeh… - …, 2017 - thelancet.com
HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …
the physiological impact of social and environmental stress, and have become a focal point …
A review of DNA methylation in depression
D Chen, L Meng, F Pei, Y Zheng, J Leng - Journal of Clinical Neuroscience, 2017 - Elsevier
As one of the most common psychiatric disorders, depression has been a major public
health problem. Growing evidence suggests that epigenetic modification is essential in …
health problem. Growing evidence suggests that epigenetic modification is essential in …