One monomeric and three oligomeric potato spindle tuber viroid (PSTVd) cDNA units were
introduced into the tobacco genome via the Agrobacterium-mediated leaf-disc …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …

DNA methylation in mammals is required for embryonic development, X chromosome
inactivation and imprinting. Previous studies have shown that methylation patterns become …

DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …

We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

Precise genetic and epigenetic spatiotemporal regulation of gene expression is critical for
proper brain development, function and circuitry formation in the mammalian central nervous …

It has been a controversial issue as to how many DNA cytosine methyltransferase
mammalian cells have and whether de novo methylation and maintenance methylation …

Embryonic stem cells (ESCs) are apparently homogeneous self-renewing cells, but we
observed heterogeneous expression of Stella in ESCs, which is a marker of pluripotency …

The period of in utero development is one of the most critical windows during which adverse
intrauterine conditions and exposures can influence the growth and development of the …

Although germline cells can form multipotential embryonic stem (ES)/embryonic germ (EG)
cells, these cells can be derived only from embryonic tissues, and such multipotent cells …