Bivalent H3K4me3 and H3K27me3 chromatin domains in embryonic stem cells keep active
developmental regulatory genes expressed at very low levels and poised for activation …

Genome‐wide epigenetic reprogramming by demethylation occurs in early mouse embryos
and primordial germ cells. In early embryos many single‐copy sequences become …

SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Epigenetic modifications constitute a complex regulatory layer on top of the genome
sequence. Pluripotent and differentiated cells provide a powerful system for investigating …

CpG island–like sequences are commonly thought to provide the sole signals for
designating constitutively unmethylated regions in the genome, thus generating open …

ANIMAL somatic cell DNA is characterized by a bimodal pattern of methylation: tissue-
specific genes are methylated in most cell types whereas housekeeping genes have 5 …

The Dnmt3a DNA methyltransferase is essential for mammalian development and is
responsible for the generation of genomic methylation patterns, which lead to transcriptional …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

The placenta provides critical transport functions between the maternal and fetal circulations
during intrauterine development. Formation of this interface relies on coordinated …