In all animals information is passed from parent to offspring via the germline, which
segregates from the soma early in development and undergoes a complex developmental …

Epigenetics is focused on understanding the control of gene expression beyond what is
encoded in the sequence of DNA. Central to growing interest in the field is the hope that …

In vitro manipulation of preimplantation mammalian embryos can influence differentiation
and growth at later stages of development. In the mouse, culture of embryonic stem (ES) …

Triplet repeat expansion diseases (TREDs) are characterized by the coincidence of disease
manifestation with amplification of d (CAG· CTG), d (CGG· CCG) or d (GAA· TTC) repeats …

Phenotypic variation in mammals is frequently attributed to the action of quantitative trait loci
(QTL) or the environment, but may also be epigenetic in origin. Here we consider a …

Imprinting, the differential expression of the two alleles of a gene based on their parental
origin, requires that the alleles be distinguished or marked. A candidate for the differentiating …

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene
regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene …

Embryo culture, nuclear transfer and asynchronous embryo transfer are procedures that can
result in the birth of larger than normal offspring. Some birthweights fall well outside the …

Spontaneous mutation rates per generation are similar among the three species considered
here—Drosophila, mouse, and human—and are not related to time, as is often assumed …

Regulation of gene expression in mammals through methylation of cytosine residues at CpG
dinucleotides is involved in the development and progression of tumors. Because many …