Epigenetic modifications characterized by DNA methylation, histone modifications, and
chromatin remodeling are important regulators in a number of biological processes …

BACKGROUND The subject of epigenetic risk of assisted reproduction treatment (ART),
initiated by reports on an increase of children with the Beckwith–Wiedemann imprinting …

Background Male-factor infertility is a common condition, and etiology is unknown for a high
proportion of cases. Abnormal epigenetic programming of the germline is proposed as a …

A male factor is implicated in more than 50% of couples treated with IVF. However, neither
the routine testing of male fertility potential nor its treatment address the specific …

BACKGROUND Successful gametogenesis requires the establishment of an appropriate
epigenetic state in developing germ cells. Nevertheless, an association between abnormal …

Gamete and early embryo development are important stages when genome-scale
epigenetic transitions are orchestrated. The apparent lack of remodeling of differential …

As assisted reproductive technologies (ARTs) are increasingly used to overcome infertility,
there is concern about the health of the children conceived. The empirical evidence for …

Background Spermatogenesis‐associated (SPATA) family of genes plays important roles in
spermatogenesis, sperm maturation or fertilization. The knockout studies in mice have …

The most common form of male infertility is a low sperm count, known as oligozoospermia.
Studies suggest that oligozoospermia is associated with epigenetic alterations. Epigenetic …

OBJECTIVE:: To determine the relationship between sperm DNA methylation level and
sperm characteristics and pregnancy rates. DESIGN:: Prospective study. Quantitation by …