Dapagliflozin ameliorates the formation and progression of experimental abdominal aortic aneurysms by reducing aortic inflammation in mice

H Liu, P Wei, W Fu, C Xia, Y Li, K Tian… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Dapagliflozin, a sodium glucose transporter protein‐2 (SGLT‐2) inhibitor,
reduces the risk for cardiovascular diseases. However, the influence of dapagliflozin on …

[HTML][HTML] C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms

Y Fu, H Liu, K Li, P Wei, N Alam, J Deng, M Li… - Frontiers in …, 2023 - frontiersin.org
Background C-reactive protein (CRP) levels are elevated in patients with abdominal aortic
aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA …

[HTML][HTML] Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms

W Fu, H Liu, P Wei, C Xia, Q Yu, K Tian, Y Li… - Frontiers in …, 2023 - frontiersin.org
Aim Signal transducer and activator of transcription (STAT) signaling is critical for the
pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated …

[PDF][PDF] 腹主动脉瘤动物模型的研究现状与转化应用

夏聪聪, 刘浩乐, 侯海雯, 刘恩岐, 赵四海 - 中国实验动物 …, 2024 - zgbjyx.cnjournals.com
Population aging in China has led to an increase in the incidence of abdominal aortic
aneurysm (AAA). AAA rupture is one of the most severe life-threatening diseases, with high …

The incidence rate and histological characteristics of intimal hyperplasia in elastase‐induced experimental abdominal aortic aneurysms in mice

M Li, P Wei, K Li, H Liu, N Alam, H Hou… - Animal Models and …, 2023 - Wiley Online Library
Intimal hyperplasia (IH) is a negative vascular remodeling after arterial injury. IH
occasionally occurs in elastase‐induced abdominal aortic aneurysm (AAA) mouse models …

[HTML][HTML] Mouse Abdominal Aortic Aneurysm Model Induced by Periarterial Incubation of Papain

YC Lin, QY Chen, J Xiao, LC Shen, XT Li, YZ Yang… - Laboratory …, 2023 - Elsevier
For decades, numerous experimental animal models have been developed to examine the
pathophysiologic mechanisms and potential treatments for abdominal aortic aneurysms …