[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Position paper of the Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), and the Italian Study Group of Diabetes in pregnancy …

L Sciacca, C Bianchi, S Burlina, G Formoso… - Acta Diabetologica, 2023 - Springer
Objective This document purpose is to create an evidence-based position statement on the
role of metformin therapy in pregnancy complicated by obesity, gestational diabetes (GDM) …

[HTML][HTML] Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone …

SS Qi, ML Shao, Z Sun, SM Chen, YJ Hu… - Frontiers in …, 2021 - frontiersin.org
Diabetic osteoporosis (DOP) belongs to secondary osteoporosis caused by diabetes; it has
the characteristics of high morbidity and high disability. In the present study, we constructed …

Association of folate and vitamin B12 imbalance with adverse pregnancy outcomes among 11,549 pregnant women: An observational cohort study

X Yuan, X Han, W Zhou, W Long, H Wang, B Yu… - Frontiers in …, 2022 - frontiersin.org
Objective This study aimed to evaluate maternal serum levels of folate, vitamin B12, and
their ratio on admission for labor and determine whether an imbalance between folate and …

Efficacy and safety of metformin during pregnancy: an update

SA Paschou, A Shalit, E Gerontiti, KI Athanasiadou… - Endocrine, 2024 - Springer
During the last decades, gestational diabetes mellitus (GDM) prevalence has been on the
rise. While insulin remains the gold standard treatment for GDM, metformin use during …

Impact of metformin on neocortical development during pregnancy: Involvement of ERK and p35/CDK5 pathways

M Oner, MC Chen, PT Cheng, YH Li, YC Cheng… - Chemosphere, 2024 - Elsevier
Metformin, the most commonly prescribed drug for the treatment of diabetes, is increasingly
used during pregnancy to address various disorders such as diabetes, obesity …

Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance

A Hufnagel, DS Fernandez‐Twinn… - The Journal of …, 2022 - Wiley Online Library
Maternal obesity is a global problem that increases the risk of short‐and long‐term adverse
outcomes for mother and child, many of which are linked to gestational diabetes mellitus …

Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006

X Pei, J Yao, S Ran, H Lu, S Yang, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Existing evidence suggests an association between certain vitamins and
metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of …

Association of folic acid supplementation in early pregnancy with risk of gestational diabetes mellitus: a longitudinal study

H Chen, Y Hu, Y Li, W Zhou, N Zhou, H Yang, Q Chen… - Nutrients, 2022 - mdpi.com
Background: Gestational diabetes mellitus (GDM) may lead to many adverse effects on
women and their offspring. Method: 24,429 pregnant women were enrolled during early …

Metformin-induced vitamin B12 deficiency among type 2 diabetes mellitus' patients: A systematic review

R Khattab, M Albannawi… - Current diabetes …, 2023 - ingentaconnect.com
Background: Type 2 diabetes mellitus is one of the most globally common chronic diseases.
Metformin is the most popular prescribed medication for the treatment of diabetes. Studies …