The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

Monoclonal gammopathies are characterized by the overproduction of monoclonal Ig (MIg)
detectable in the serum or urine resulting from a clonal proliferation of plasma cells or B …

In both atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G)
complement plays a primary role in disease pathogenesis. Herein we report the outcome of …

Renal pathologists and nephrologists met on February 20, 2015 to establish an
etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim …

Glomerulonephritis (GN) is an important cause of morbidity and mortality in patients of all
ages throughout the world. Because these disorders are relatively rare, it is difficult to …

Glomerulonephritis is a heterogeneous group of disorders that present with a combination of
haematuria, proteinuria, hypertension, and reduction in kidney function to a variable degree …

Results Eighty patients with C3 glomerulopathy were identified: 21 with DDD and 59 with
C3GN. Patients with DDD were younger, more likely to have low serum C3 levels, and more …

In the past, most cases of bacterial infection–related glomerulonephritis (IRGN) occurred in
children following streptococcal upper respiratory tract or skin infections and were called …

C3 glomerulonephritis (C3GN) and dense deposit disease comprise the two classes of C3
glomerulopathy. Studies from Europe and Asia have aided our understanding of this …

C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or
dominant deposits of C3 on immunofluorescence. To explore the effect of …