Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we
tested hierarchical immunofluorescence criteria with varying stringency for C3 …

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the
severity of the lesion, to identify whether other lesions, related to or not related to the GN, are …

Monoclonal gammopathy of undetermined significance (MGUS) is, in many ways, a unique
hematologic entity. Unlike most hematologic conditions in which the diagnosis is intentional …

Recurrent glomerulonephritis (GN) is an important cause of kidney allograft failure,
particularly in younger recipients. Approximately 15% of death-censored graft failures are …

Postinfectious glomerulonephritis is a common disorder that develops following an infection.
In the majority of cases, there is complete recovery of renal function within a few days to …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

Abstract C3 glomerulonephritis (C3GN) results from abnormalities in the alternative pathway
of complement, and it is characterized by deposition of C3 with absent or scant Ig deposition …

Atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy (C3G), and paroxysmal
nocturnal hemoglobinuria (PNH) are prototypical disorders of complement dysregulation …

Background Cases reports and small series of patients with C3 glomerulopathy have
reported variable efficacy of eculizumab. Study Design Case series of C3 glomerulopathy …

Objective To describe the clinicopathological features, complement abnormalities, triggers,
treatment, and outcomes of C3 glomerulopathy. Patients and Methods A total of 114 patients …