Background C3 glomerulonephritis (GN) is a proliferative GN resulting from glomerular
deposition of complement factors due to dysregulation of the alternative pathway of …

Monoclonal immunoglobulins (MIg) may play a causal role in C3 glomerulopathy (C3G) by
impairing regulation of the alternative pathway of complement. Ninety-five patients with C3G …

Until recently, membranoproliferative glomerulonephritis (MPGN) was clinically classified as
either primary, idiopathic MPGN or as secondary MPGN when an underlying aetiology was …

The prevalence, pathogenesis, predictors, and natural course of patients with recurrent
glomerulonephritis (GN) occurring after kidney transplantation remains incompletely …

Dysregulation of the complement system is linked to the pathogenesis of a variety of
hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the …

Proliferative GN is classified as immune complex-mediated or complement-mediated (C3
glomerulopathy). Immune complex-mediated GN results from glomerular deposition of …

Despite major advances in understanding genetic predispositions ('first hits'), pathogenic
immune responses, and the mediators of tissue injury in glomerulonephritis (GN), there …

The complement is a powerful cascade of the innate immunity and also acts as a bridge
between innate and acquired immune defence. Complement activation can occur via three …

Introduction Membranous nephropathy (MN) is the most common cause of nephrotic
syndrome in Caucasian adults. Phospholipase A2 receptor (PLA2R)–and exostosin 1 …

C3 glomerulopathy (C3G) is a prototypic complement-mediated kidney disease. Rapidly
progressive forms of C3G usually respond poorly to conventional treatments. We report on …