Monoclonal gammopathy are associated with a variety of kidney diseases. The monoclonal
gammopathy-associated renal diseases are distinct in their pathogenesis, kidney biopsy …

Kidney diseases resulting from abnormal control of the complement alternative pathway
include atypical hemolytic uremic syndrome, C3 glomerulonephritis, and dense-deposit …

Kidney diseases caused by genetic or acquired dysregulation of the complement alternative
pathway (AP) are traditionally classified on the basis of clinical presentation (atypical …

C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated
with C3 cleavage product deposition and with defective complement action and regulation …

Monoclonal gammopathy is characterized by circulating monoclonal immunoglobulin owing
to clonal proliferation of immunoglobulin-producing B lymphocytes or plasma cells. Clonal …

Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are widely recognized
subtypes of C3 glomerulopathy. These ultra-rare renal diseases are characterized by fluid …

Nephritis-associated plasmin receptor (NAPlr) was originally isolated from the cytoplasmic
fraction of group A Streptococci, and was found to be the same molecule as streptococcal …

C3 glomerulopathy refers to those renal lesions characterized histologically by predominant
C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the …

Background Complement activation plays an important role in the pathophysiology of anti-
neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), although it remains …

The complement (C) cascade is an ancient system of proteins whose primary role is to
initiate and modulate immune responses. During C activation, circulating proteins are …