C3 glomerulopathy is a recent disease classification comprising several rare types of
glomerulonephritis, including dense deposit disease (DDD) and C3 glomerulonephritis …

A major shift in our understanding of the membranoproliferative glomerulonephritis (MPGN)
lesion is the focus on which components of the complement pathway are involved in …

Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic
syndrome (aHUS) and complement component 3 glomerulopathy (C3G). Complement …

C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases
caused by abnormal control of complement activation with deposition of complement …

The recurrence of renal disease after renal transplantation is becoming one of the main
causes of graft loss after kidney transplantation. This principally concerns some of the …

Membranoproliferative glomerulonephritis (MPGN) has been classified based on its
pathogenesis into immune complex-mediated and complement-mediated MPGN. The …

Monoclonal Ig deposition disease (MIDD) is a rare complication of monoclonal gammopathy
characterized by deposition of monoclonal Ig light chains and/or heavy chains along the …

The kidney is often the target of immune system dysregulation in the context of primary or
systemic disease. In particular, the glomerulus represents the anatomical entity most …

The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by
dysregulation of the alternative pathway (AP) of the complement system. C3G is often …

Nephritic factors (NeFs) are autoantibodies promoting the activity of the central enzymes of
the complement cascade, an important first line of defense of our innate immune system …