The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

The three-way connection between DNA methylation, gene activity and chromatin structure
has been known for almost two decades. Nevertheless, the molecular link between methyl …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

We have used a combination of genetics and pharmacology to assess the effects of reduced
DNA methyltransferase activity on ApcM~"-induced intestinal neoplasia in mice. A reduction …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

Genomic reprogramming of primordial germ cells (PGCs), which includes genome‐wide
demethylation, prevents aberrant epigenetic modifications from being transmitted to …

Methylation patterns of the mammalian genome are thought to be crucial for development.
The precise mechanisms designating specific genomic loci for methylation are not known …

To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …

One of the most important criteria for successful generation of a therapeutic protein from a
recombinant cell is to obtain a cell line that maintains stability of production. If this is not …