It is generally believed that specific demethylation processes take place in the promoter of
tissue-specific genes during development. It has been suggested that hypomethylation of …

We investigated the role of DNA methylation in gene regulation of the rat T-cell
differentiation marker RT6. Analysis of the methylation status of various tissues revealed that …

The molecular complex consisting of DNA and its associated proteins is referred to as
chromatin. In the central nervous system (CNS), dynamic chromatin remodelling is required …

The terminal deoxynucleotidyl transferase gene (TdT) is expressed in mice only in early B
and T lymphoid precursors a few days after birth. Transactivating factors have been shown …

The possible role of DNA methylation changes during several. commitment steps of
immature myeloid precursor cells toward functional, terminally differentiated phagocyte cells …

表观遗传学主要关注DNA 甲基化、 组蛋白修饰、 染色质重塑， 以及非编码RNA 等超越DNA
序列的基因调控机制。 表观遗传机制参与了个体发育、 细胞命运决定和肿瘤发生等众多生物学 …

We have analyzed the ontogenic initiation and maintenance of methylation of certain HpaII
(m), HhaI (H), HincII (Hc), and SalI (SI)‐specific CpG sites in the coding region of the proto …

To the Editor: Methylation patterns are tissue-specific (1). Methylation studies are therefore
ideally performed in the tissue that is directly related to the disease of interest. However, for …

Epigenetic alterations of DNA play key roles in determining gene structure and expression.
Methylation of the 5-position of cytosine is thought to be the most common modification of …

Humoral hypercalcaemia of malignancy often results from production of parathyroid
hormone-related protein (PTHrP) by the tumour. We have investigated whether malignancy …