Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …

Importance Tranexamic acid is recommended for reducing blood loss and transfusion in
cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid …

USING STRATEGIES TO mitigate blood loss and the need for transfusion is a fundamental
component of caring for surgical patients. Antifibrinolytic use is standard practice for complex …

Background: The optimal dose of tranexamic acid (TA) is still an issue. The authors
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …

We conducted a study to assess pharmacokinetics of high‐dose tranexamic acid for 24 h
after administration of the drug in patients undergoing cardiac surgery with cardiopulmonary …

BACKGROUND: Neonates are at high risk for bleeding complications after cardiovascular
surgery. Activation of intravascular fibrinolysis is one of the principal effects of …

Antifibrinolytic agents are used during cardiac surgery to minimize bleeding and reduce
exposure to blood products. Several reports suggest that tranexamic acid (TA) can induce …

BACKGROUND: Tranexamic acid is a synthetic lysine analog used for management of
bleeding disorders. The objective of this study was first to develop a method for …

Background The identification of safe and effective alternatives to blood transfusion is a
public health priority. In sub-Saharan Africa, blood shortage is a cause of mortality and …

Background Tranexamic acid (TxA) reduces perioperative blood transfusion in cardiac
surgery; however, the optimal dose of TxA remains unknown. Methods and results This large …