BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

Cryopreservation has important application in assisted reproductive technology (ART). The
vitrification technique has been widely used in the cryopreservation of oocytes and embryos …

Hydatidiform moles are intriguing pathologic entities representing abnormal placental villous
tissue with unique genetic profiles and a wide spectrum of morphologic features, which …

Early stages of mammalian embryonic development are now known to be very sensitive to
their microenvironment, with long term effects on fetal, postnatal, and adult health, thus …

STUDY QUESTION Are preconception phthalate and phthalate replacements associated
with sperm differentially methylated regions (DMRs) among men undergoing IVF …

Living organisms are constantly exposed to wide ranges of environmental cues. They react
to these cues by undergoing a battery of phenotypic responses, such as by altering their …

Male germ cells require multiple epigenetic reprogramming events during their lifespan to
achieve reproductive capacity. An emerging body of compelling data demonstrates that …

Genomic imprinting is an epigenetic process regulated by germline-derived DNA
methylation that is resistant to embryonic reprogramming, resulting in parental origin-specific …

Thousands of regions in gametes have opposing methylation profiles that are largely
resolved during the post-fertilization epigenetic reprogramming. However some specific …