Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

To elucidate principles operating in native biological systems and to develop novel
biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within …

Chromatin consists of a complex of DNA and histone proteins as its core components and
plays an important role in both packaging DNA and regulating DNA metabolic pathways …

Digestive cancers are the leading cause of cancer-related death worldwide and have high
risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine …

The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …

In some mammals, notably humans, recombination occurs almost exclusively where the
protein PRDM9 binds, whereas in vertebrates lacking an intact PRDM9, such as birds and …

Precise control of activating H3K4me3 and repressive H3K27me3 histone modifications at
bivalent promoters is essential for normal development and frequently corrupted in cancer …

Transcriptional regulation is commonly governed by alternative promoters. However, the
regulatory architecture in alternative and reference promoters, and how they differ, remains …

Epigenetics represents a widely accepted set of mechanisms by which organisms respond
to the environment by regulating phenotypic plasticity and life history transitions …