Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for
earlier detection of triple‐negative breast cancer (TNBC) which could help clinicians with …

Trait-associated loci often map to genomic regions encoding long noncoding RNAs
(lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show …

Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is
relevant to establish resistance to therapeutic approaches. The use of compounds direct …

Neuroblastoma is the most common solid tumor in children under the age of one. It displays
remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with …

DNA methylation is the most studied epigenetic modification due to its role in regulating
gene expression, and its involvement in the pathogenesis of cancer and several diseases …

Pediatric solid tumors have long been known to shed tumor cells, DNA, RNA, and proteins
into the blood. Recent technological advances have allowed for improved capture and …

Background Neuroblastoma is the most common malignancy in infancy, accounting for 15%
of childhood cancer deaths. Outcome for the high-risk disease remains poor. DNA …

Neuroblastoma, a neoplasm of the sympathetic nervous system, originates from
neuroblastoma stem cells during embryogenesis. It exhibits unique clinical features …

In recent years, technological advances have enabled a detailed landscaping of the
epigenome and the mechanisms of epigenetic regulation that drive normal cell function …