Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
[HTML][HTML] DNA methylation markers in the detection of hepatocellular carcinoma
S Fu, JD Debes, A Boonstra - European Journal of Cancer, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
V Ortiz-Barahona, M Soler, V Davalos… - Molecular Cancer, 2023 - Springer
Background RNA modifications are important regulators of transcript activity and an
increasingly emerging body of data suggests that the epitranscriptome and its associated …
increasingly emerging body of data suggests that the epitranscriptome and its associated …
Epigenetic modification-related mechanisms of hepatocellular carcinoma resistance to immune checkpoint inhibition
S Tao, S Liang, T Zeng, D Yin - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) constitutes most primary liver cancers and is one of the
most lethal and life-threatening malignancies globally. Unfortunately, a substantial …
most lethal and life-threatening malignancies globally. Unfortunately, a substantial …
Genetics of hepatocellular carcinoma: from tumor to circulating DNA
C Campani, J Zucman-Rossi, JC Nault - Cancers, 2023 - mdpi.com
Simple Summary In recent years, the genetic landscape of hepatocellular carcinoma (HCC)
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …
UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma
Y Wang, P Hu, F Wang, S Xi, S Wu, L Sun, Y Du… - Cell Death & …, 2023 - nature.com
Cancer stem cells (CSCs) contribute to tumor initiation, progression, and recurrence in many
types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of …
types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of …
HCC biomarkers–state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice
S Schlosser, D Tümen, B Volz, K Neumeyer… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide.
Management of HCC depends on reliable biomarkers for screening, diagnosis, and …
Management of HCC depends on reliable biomarkers for screening, diagnosis, and …
The role of liquid biopsy in hepatocellular carcinoma prognostication
Simple Summary Hepatocellular carcinoma (HCC) is one of the deadliest cancer. Clinical
guidelines for the management of HCC endorse algorithms deriving from clinical variables …
guidelines for the management of HCC endorse algorithms deriving from clinical variables …
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
M Chen, Y Fang, M Liang, N Zhang, X Zhang… - Journal of Translational …, 2023 - Springer
Background Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and
DNA methylation patterns have been shown to be closely associated with tumor progression …
DNA methylation patterns have been shown to be closely associated with tumor progression …
Methylomics and cancer: the current state of methylation profiling and marker development for clinical care
C Liu, H Tang, N Hu, T Li - Cancer Cell International, 2023 - Springer
Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …
regulation linking behavior and environmental conditions or stimuli with biological …