Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

[HTML][HTML] DNA methylation markers in the detection of hepatocellular carcinoma

S Fu, JD Debes, A Boonstra - European Journal of Cancer, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a
poor prognosis. Epigenetic modification has been shown to be deregulated during HCC …

Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

V Ortiz-Barahona, M Soler, V Davalos… - Molecular Cancer, 2023 - Springer
Background RNA modifications are important regulators of transcript activity and an
increasingly emerging body of data suggests that the epitranscriptome and its associated …

Epigenetic modification-related mechanisms of hepatocellular carcinoma resistance to immune checkpoint inhibition

S Tao, S Liang, T Zeng, D Yin - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) constitutes most primary liver cancers and is one of the
most lethal and life-threatening malignancies globally. Unfortunately, a substantial …

Genetics of hepatocellular carcinoma: from tumor to circulating DNA

C Campani, J Zucman-Rossi, JC Nault - Cancers, 2023 - mdpi.com
Simple Summary In recent years, the genetic landscape of hepatocellular carcinoma (HCC)
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …

UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma

Y Wang, P Hu, F Wang, S Xi, S Wu, L Sun, Y Du… - Cell Death & …, 2023 - nature.com
Cancer stem cells (CSCs) contribute to tumor initiation, progression, and recurrence in many
types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of …

HCC biomarkers–state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice

S Schlosser, D Tümen, B Volz, K Neumeyer… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide.
Management of HCC depends on reliable biomarkers for screening, diagnosis, and …

The role of liquid biopsy in hepatocellular carcinoma prognostication

I Labgaa, A Villanueva, O Dormond, N Demartines… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the deadliest cancer. Clinical
guidelines for the management of HCC endorse algorithms deriving from clinical variables …

The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma

M Chen, Y Fang, M Liang, N Zhang, X Zhang… - Journal of Translational …, 2023 - Springer
Background Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and
DNA methylation patterns have been shown to be closely associated with tumor progression …

Methylomics and cancer: the current state of methylation profiling and marker development for clinical care

C Liu, H Tang, N Hu, T Li - Cancer Cell International, 2023 - Springer
Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …