Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Autosomal-
dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic …

Polycystins are a family of eight-transmembrane proteins united by sequence homology.
The name stems from the identification of mutations in genes encoding polycystin-1 and-2 in …

Autosomal dominant polycystic kidney disease (ADPKD) gene products polycystin-1 (PC1)
and polycystin-2 (PC2) colocalize in the apical monocilia of renal epithelial cells. Mouse and …

Polycystin-1 is a modular membrane protein with a long extracellular N-terminal portion that
bears several ligand-binding domains, 11 transmembrane domains, and a≥ 200 amino …

Autosomal dominant polycystic kidney disease (ADPKD) is a major, inherited disorder that is
characterized by the growth of large, fluid-filled cysts from the tubules and collecting ducts of …

▪ Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a common and
systemic disease characterized by formation of focal cysts. Of the three potential causes of …

Local regulation of vascular tone plays an important role in cardiovascular control of blood
pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly …

The PKD1 gene, encoding protein polycystin-1 (PC1), is responsible for 85% of cases of
autosomal dominant polycystic kidney disease (ADPKD). PC1 has been shown to be …

Objective: Several members of the PKD gene family (PKD2, PKDL and PKD2L2) are
expressed in the heart. Polycystin-2 and its homologues, which are encoded by these …