Cancer chemoprevention by dietary polyphenols: promising role for epigenetics
Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …
play an important role in the control of gene expression. In mammals, epigenetic …
New modes of action for endocrine-disrupting chemicals
MM Tabb, B Blumberg - Molecular endocrinology, 2006 - academic.oup.com
Endocrine-disrupting chemicals (EDC) are commonly considered to be compounds that
mimic or block the transcriptional activation elicited by naturally circulating steroid hormones …
mimic or block the transcriptional activation elicited by naturally circulating steroid hormones …
Downregulation of SNCA expression by targeted editing of DNA methylation: a potential strategy for precision therapy in PD
B Kantor, L Tagliafierro, J Gu, ME Zamora, E Ilich… - Molecular therapy, 2018 - cell.com
Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson's disease
(PD), while normal physiological levels of SNCA are needed to maintain neuronal function …
(PD), while normal physiological levels of SNCA are needed to maintain neuronal function …
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic …
Background—Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn …
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn …
Growth hormone regulation of sex-dependent liver gene expression
DJ Waxman, C O'Connor - Molecular endocrinology, 2006 - academic.oup.com
The liver is a primary target for the action of GH, a pituitary protein hormone that regulates a
broad range of physiological processes, including long bone growth, fatty acid oxidation …
broad range of physiological processes, including long bone growth, fatty acid oxidation …
Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases
Endocrine-disrupting chemicals (EDC), including phthalates, bisphenol A (BPA),
phytoestrogens such as genistein and daidzein, dichlorodiphenyltrichloroethane (DDT), and …
phytoestrogens such as genistein and daidzein, dichlorodiphenyltrichloroethane (DDT), and …
Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer
Y Zhang, R Wang, H Song, G Huang, J Yi, Y Zheng… - Cancer letters, 2011 - Elsevier
Aberrant DNA methylation is a common phenomenon in human cancer. The aims of this
study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in …
study were to investigate the methylation profiles of non-small cell lung cancer (NSCLC) in …
Parabens in male infertility—Is there a mitochondrial connection?
RS Tavares, FC Martins, PJ Oliveira… - Reproductive …, 2009 - Elsevier
Parabens are widely used as preservatives in many foods, cosmetics, toiletries, and
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use …
pharmaceuticals due to their relatively low toxicity profile and to a long history of safe use …
Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples
Aberrant methylation is one of the most frequent epigenetic alterations that can contribute to
tumor formation. Cell-free DNA can originate from tumor tissue; therefore, the evaluation of …
tumor formation. Cell-free DNA can originate from tumor tissue; therefore, the evaluation of …
Epigenetic modification of gene expression in cancer cells by terahertz demethylation
Terahertz (THz) radiation can affect the degree of DNA methylation, the spectral
characteristics of which exist in the terahertz region. DNA methylation is an epigenetic …
characteristics of which exist in the terahertz region. DNA methylation is an epigenetic …