Gene ranking is an important problem in bioinformatics. Here, we propose a new framework
for ranking biomolecules (viz., miRNAs, transcription-factors/TFs and genes) in a multi …

Safely and efficiently controlling gene expression is a long-standing goal of biomedical
research, and the recently discovered bacterial CRISPR/Cas system can be harnessed to …

Schizophrenia is a complex mental disorder with high heritability (80%), extensive genetic
heterogeneity, environmental contributions and only 50% concordance in discordant …

Background The membrane transporters such as P-glycoprotein (Pgp), the MDR1 gene
product, are one of causes of treatment failure in cancer patients. In this study, the epigenetic …

Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland.
The mechanism underlying ACC carcinogenesis is not fully elucidated, although data on …

Evidence for involvement of DNA methylation in psychosis forms the focus of this
perspective. Of interest are results from two independent sets of experiments including rats …

The use of hiPSC-derived cells represents a valuable approach to study human
neurodegenerative diseases. Here, we describe an optimized protocol for the differentiation …

Martinelli M, Masiero E, Carinci F, Morselli PG, Pezzetti F, Scapoli L. New evidence for the
role of cystathionine beta‐synthase in non‐syndromic cleft lip with or without cleft palate. Eur …

Проведен критический анализ факторов, обусловливающих фенотип. Показано, что
этих факторов четыре: исходные наследственные задатки организма, закономерности …

Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune
disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is characterized …