Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland.
The mechanism underlying ACC carcinogenesis is not fully elucidated, although data on …

Background The membrane transporters such as P-glycoprotein (Pgp), the MDR1 gene
product, are one of causes of treatment failure in cancer patients. In this study, the epigenetic …

Background It has been shown that methylation in the promoter region of eNOS can
downregulate eNOS expression resulting in the endothelial dysfunction. However, it is …

Background Hepatocellular carcinoma (HCC), the seventh most common cancer worldwide,
is characterized by a high mortality rate, advanced diagnosis, and susceptibility to …

Evidence for involvement of DNA methylation in psychosis forms the focus of this
perspective. Of interest are results from two independent sets of experiments including rats …

Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune
disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is characterized …

Martinelli M, Masiero E, Carinci F, Morselli PG, Pezzetti F, Scapoli L. New evidence for the
role of cystathionine beta‐synthase in non‐syndromic cleft lip with or without cleft palate. Eur …

Safely and efficiently controlling gene expression is a long-standing goal of biomedical
research, and the recently discovered bacterial CRISPR/Cas system can be harnessed to …

Проведен критический анализ факторов, обусловливающих фенотип. Показано, что
этих факторов четыре: исходные наследственные задатки организма, закономерности …

Promoter hypermethylation can lead to a loss of genetic imprinting in carcinogenesis. The
mechanism for the loss of expression of the imprinted gene TSSC3 has not been …