Genetics and epigenetics in obesity
K Rohde, M Keller, L la Cour Poulsen, M Blüher… - Metabolism, 2019 - Elsevier
Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …
markedly increased over the last decades. Obesity maybe considered a heritable trait …
[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
Human DNA methylomes at base resolution show widespread epigenomic differences
DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …
cellular processes including genome regulation, development and disease. Here we …
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
L Luzhna, P Kathiria, O Kovalchuk - Frontiers in genetics, 2013 - frontiersin.org
Micronuclei (MN) are extra-nuclear bodies that contain damaged chromosome fragments
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
and/or whole chromosomes that were not incorporated into the nucleus after cell division …
Epigenetics and gene expression
ER Gibney, CM Nolan - Heredity, 2010 - nature.com
Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …
Linking DNA methylation and histone modification: patterns and paradigms
H Cedar, Y Bergman - Nature Reviews Genetics, 2009 - nature.com
Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …
repression during development. Certain forms of histone methylation cause local formation …
Regulation and function of DNA methylation in plants and animals
DNA methylation is an important epigenetic mark involved in diverse biological processes.
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
In plants, DNA methylation can be established through the RNA-directed DNA methylation …
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
Background We recently showed that enzymes of the TET family convert 5-mC to 5-
hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem …
hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is present at high levels in embryonic stem …
Epigenetics and the placenta
ECM Nelissen, APA van Montfoort… - Human reproduction …, 2011 - academic.oup.com
BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …
MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome
Epigenetic mechanisms, such as DNA methylation, regulate transcriptional programs to
afford the genome flexibility in responding to developmental and environmental cues in …
afford the genome flexibility in responding to developmental and environmental cues in …