Five novel diacylated sulfoglycolipids (1− 5) were isolated from the cyanobacterium
Scytonema sp.(TAU strain SL-30-1-4) and four novel acylated diglycolipids (6− 9) were …

抄録 A new sulfolipid, KM043, which belongs to the 6-sulfo-α-D-quinovopyranosyl-(1→ 3')-1',
2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga …

Polycitone A, an aromatic alkaloid isolated from the ascidian Polycitor sp. exhibits potent
inhibitory capacity of both RNA-and DNA-directed DNA polymerases. The drug inhibits …

Prenylated hydroquinones and related metabolites have been isolated from marine
organisms with a terpenoid portion that ranges from one to nine isoprene units. Triprenyl …

The marine environment is a rich source of both biological and chemical diversity. This
diversity has been the source of unique chemical compounds with potential for drug …

We used molecular modeling to design de novo broad-range inhibitors against wild type
and drug-resistant variants of the reverse transcriptase (RT) of human immunodeficiency …

Polyacetylenetriol (PAT), a natural marine product from the Mediterranean sea sponge
Petrosia sp., was found to be a novel general potent inhibitor of DNA polymerases. It inhibits …

The reverse transcriptase (RT) of human immunodeficiency virus type-1 (HIV-1) is a leading
target in current antiretroviral therapy. Unfortunately, drug-resistant RT mutants evolve under …

The human immunodeficiency virus (HIV) epidemic is an important medical problem.
Although combination drug regimens have produced dramatic decreases in viral load …

The RT (reverse transcriptase) of HIV-1 interacts with HIV-1 IN (integrase) and inhibits its
enzymatic activities. However, the molecular mechanisms underling these interactions are …