The maternal diet during pregnancy is a key determinant of offspring health. Early studies
have linked poor maternal nutrition during gestation with a propensity for the development of …

Data derived from high-throughput sequencing technologies have allowed a deeper
understanding of the molecular landscape of Acute Myeloid Leukemia (AML), paving the …

Simple Summary Acute Myeloid Leukemias (AMLs) are rapidly progressive clonal
neoplastic diseases. The overall 5-year survival rate is very poor: less than 5% in older …

Vitamin C has been demonstrated to regulate hematopoietic stem cell frequencies and
leukemogenesis by augmenting and restoring Ten-Eleven Translocation-2 (TET2) function …

Simple Summary The tumor microenvironment (TME) is a complicated network, and several
promising TME-targeted therapies, such as immunotherapy and targeted therapies, are now …

Identifying how specific nutrients can impact fertility, pregnancy, and neonatal outcomes will
yield important insights into the biological mechanisms linking diet and reproductive health …

The tumor microenvironment (TME) plays an essential role in the development, proliferation,
and survival of leukemic blasts in acute myeloid leukemia (AML). Within the bone marrow …

Simple Summary Recent advances in exome sequencing and comprehensive genomic
studies have shed new light on the pathogenesis and mutational landscape of …

Ascorbate plays a vital role as a co-factor for a superfamily of enzymes, the 2-oxoglutarate
dependent dioxygenases (2-OGDDs), which govern numerous pathways in cancer …

While considerable information exists on the ten-eleven translocation 2 (TET2) mutational
landscape in AML, the information on TET2 expression is limiting. So, we aimed to study the …