Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

Neuropeptides are auxiliary messenger molecules that always co-exist in nerve cells with
one or more small molecule (classic) neurotransmitters. Neuropeptides act both as …

Introduction: Most medical diagnoses present somewhat differently in men and women,
more so at specific periods of life. Treatment effects may also differ. This is true for …

Major depressive disorder (MDD or depression) is a debilitating neuropsychiatric syndrome
with genetic, epigenetic, and environmental contributions. Depression is one of the largest …

The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major
chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for …

MRI has enhanced our capacity to understand variations in brain structure and function
conferred by the genome. We identified 60 studies that report associations between DNA …

Methylation is an essential biochemical mechanism that is central to the transmission of life,
and crucially responsible for regulating gametogenesis and continued embryo development …

Mental health modulates the risk of common chronic conditions. Although inflammation is
thought to partly explain this link, its relation with mental health is still unclear and largely …