Smoking changes adaptive immunity with persistent effects
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
T Xiao, J Lee, TD Gauntner, M Velegraki… - Nature Reviews …, 2024 - nature.com
Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …
individuals generally experiencing higher incidence of cancer with poorer outcomes …
Rare diseases of epigenetic origin: Challenges and opportunities
Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect
approximately 350 million people worldwide. Progress in next-generation sequencing …
approximately 350 million people worldwide. Progress in next-generation sequencing …
Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects
Bulk-tissue molecular quantitative trait loci (QTLs) have been the starting point for
interpreting disease-associated variants, and context-specific QTLs show particular …
interpreting disease-associated variants, and context-specific QTLs show particular …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …
Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
United States. Decades before motor symptoms manifest, non-motor symptoms such as …
United States. Decades before motor symptoms manifest, non-motor symptoms such as …
The inactive X chromosome accumulates widespread epigenetic variability with age
Y Liu, L Sinke, TH Jonkman, RC Slieker… - Clinical …, 2023 - Springer
Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …
The cutting edge of epigenetic clocks: In search of mechanisms linking aging and mental health
Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …
mortality. Recent studies demonstrate that this link between mental health and aging is …
Introduction to epigenetics
Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas
In this study, we attempted to find genetic variants affecting gene expression (eQTL=
expression Quantitative Trait Loci) in the human placenta in normal and pathological …
expression Quantitative Trait Loci) in the human placenta in normal and pathological …