Malignancies are characterized by extensive global reprogramming of epigenetic patterns,
including gains or losses in DNA methylation and changes to histone marks. Furthermore …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably
succumb to the disease. Progression to CRPC after androgen ablation therapy is …

Prostate cancers remain indolent in the majority of individuals but behave aggressively in a
minority,. The molecular basis for this clinical heterogeneity remains incompletely …

Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to
the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell …

Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC); however, the molecular mechanisms …

Multiple genetic and epigenetic events characterize tumor progression and define the
identity of the tumors. Advances in high-throughput technologies, like gene expression …

Overexpression of the histone methyltransferase MMSET in t (4; 14)+ multiple myeloma
patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma …

Abstract Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces
histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription …

The nuclear receptor–binding SET Domain (NSD) family of histone H3 lysine 36
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …