Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Mitochondria are increasingly recognized as key players in genetic and acquired renal
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
diseases. Most mitochondrial cytopathies that cause renal symptoms are characterized by …
Mitochondria related cell death modalities and disease
C Tian, Y Liu, Z Li, P Zhu, M Zhao - Frontiers in Cell and …, 2022 - frontiersin.org
Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …
A 14-day limit for bioethics: the debate over human embryo research
G Cavaliere - BMC medical ethics, 2017 - Springer
Background This article explores the reasons in favour of revising and extending the current
14-day statutory limit to maintaining human embryos in culture. This limit is enshrined in law …
14-day statutory limit to maintaining human embryos in culture. This limit is enshrined in law …
Role of abnormal energy metabolism in the progression of chronic kidney disease and drug intervention
X Liu, H Du, Y Sun, L Shao - Renal failure, 2022 - Taylor & Francis
Chronic kidney disease (CKD) is a severe clinical syndrome with significant socioeconomic
impact worldwide. Orderly energy metabolism is essential for normal kidney function and …
impact worldwide. Orderly energy metabolism is essential for normal kidney function and …
Genome editing and assisted reproduction: curing embryos, society or prospective parents?
G Cavaliere - Medicine, health care and philosophy, 2018 - Springer
This paper explores the ethics of introducing genome-editing technologies as a new
reproductive option. In particular, it focuses on whether genome editing can be considered a …
reproductive option. In particular, it focuses on whether genome editing can be considered a …
Revising, correcting, and transferring genes
B Cwik - The American Journal of Bioethics, 2020 - Taylor & Francis
The distinction between germline and somatic gene editing is fundamental to the ethics of
human gene editing. Multiple conferences of scientists, ethicists, and policymakers, and …
human gene editing. Multiple conferences of scientists, ethicists, and policymakers, and …
Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy
S Schleidgen, HG Dederer, S Sgodda, S Cravcisin… - BMC Medical …, 2020 - Springer
Abstract Background Clustered Regularly Interspaced Short Palindromic Repeats-
associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene …
associated (CRISPR-Cas) technology may allow for efficient and highly targeted gene …
How and why to replace the 14-day rule
S Chan - Current Stem Cell Reports, 2018 - Springer
Abstract Purpose of Review The '14-day rule', which limits research on human embryos to
the first 14 days after fertilisation, has long been a pillar of regulation in this contested area …
the first 14 days after fertilisation, has long been a pillar of regulation in this contested area …
Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship
G Cavaliere, C Palacios-González - Journal of medical ethics, 2018 - jme.bmj.com
In this paper, we argue that lesbian couples who wish to have children who are genetically
related to both of them should be allowed access to mitochondrial replacement techniques …
related to both of them should be allowed access to mitochondrial replacement techniques …
He Jiankui´ s gene‐editing experiment and the non‐identity problem
M Alonso, J Savulescu - Bioethics, 2021 - Wiley Online Library
Genetic engineering has been a topic of discussion for over 50 years, but it is only recently
that gene editing has become a reality. CRISPR biotechnologies have made gene editing …
that gene editing has become a reality. CRISPR biotechnologies have made gene editing …