Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Integrated molecular analysis of human cancer has yielded molecular classification for
precise management of cancer patients. Here, we analyzed the whole genomic …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those
who are younger than 50 years have been well established. These trends have spurred …

Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …

DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …