Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke
We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …
BOLD signal physiology: models and applications
CJ Gauthier, AP Fan - Neuroimage, 2019 - Elsevier
The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …
Contribution of susceptibility-weighted imaging to acute stroke assessment
M Hermier, N Nighoghossian - Stroke, 2004 - Am Heart Assoc
Background—Susceptibility-weighted (SW) MRI provides insight into the pathophysiology of
acute stroke. We report on the use of SW imaging (SWI) sequences in clinical practice and …
acute stroke. We report on the use of SW imaging (SWI) sequences in clinical practice and …
Noninvasive quantification of whole‐brain cerebral metabolic rate of oxygen (CMRO2) by MRI
Cerebral metabolic rate of oxygen (CMRO2) is an important marker for brain function and
brain health. Existing techniques for quantification of CMRO2 with positron emission …
brain health. Existing techniques for quantification of CMRO2 with positron emission …
QUantitative Imaging of eXtraction of oxygen and TIssue consumption (QUIXOTIC) using venular‐targeted velocity‐selective spin labeling
DS Bolar, BR Rosen, AG Sorensen… - Magnetic resonance …, 2011 - Wiley Online Library
While oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are
fundamental parameters of brain health and function, a robust MRI‐based mapping of OEF …
fundamental parameters of brain health and function, a robust MRI‐based mapping of OEF …
[HTML][HTML] Cerebral hemodynamic changes of mild traumatic brain injury at the acute stage
H Doshi, N Wiseman, J Liu, W Wang, RD Welch… - PloS one, 2015 - journals.plos.org
Mild traumatic brain injury (mTBI) is a significant public health care burden in the United
States. However, we lack a detailed understanding of the pathophysiology following mTBI …
States. However, we lack a detailed understanding of the pathophysiology following mTBI …
Oxygen extraction fraction measurement using quantitative susceptibility mapping: comparison with positron emission tomography
The purposes of this study are to establish oxygen extraction fraction (OEF) measurements
using quantitative susceptibility mapping (QSM) of magnetic resonance imaging (MRI), and …
using quantitative susceptibility mapping (QSM) of magnetic resonance imaging (MRI), and …
Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia
Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia
(SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …
(SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …
Hemodynamic and permeability changes in posterior reversible encephalopathy syndrome measured by dynamic susceptibility perfusion-weighted MR imaging
BACKGROUND AND PURPOSE: The physiological mechanism that gives rise to posterior
reversible encephalopathy syndrome (PRES) is currently unknown. We sought to better …
reversible encephalopathy syndrome (PRES) is currently unknown. We sought to better …
[HTML][HTML] Neuroimaging methods to map in vivo changes of OXPHOS and oxidative stress in neurodegenerative disorders
J Prasuhn, L Kunert, N Brüggemann - International Journal of Molecular …, 2022 - mdpi.com
Mitochondrial dysfunction is a pathophysiological hallmark of most neurodegenerative
diseases. Several clinical trials targeting mitochondrial dysfunction have been performed …
diseases. Several clinical trials targeting mitochondrial dysfunction have been performed …