Development from fertilized egg to functioning multi-cellular organism requires precision.
There is no precision, and often no survival, without plasticity. Plasticity is conferred partly by …

The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …

Mitochondrial diseases are a group of common inherited diseases causing disruption of
oxidative phosphorylation. Some patients with mitochondrial disease have endocrine …

Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations
linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand …

Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

The human brain consumes five orders of magnitude more energy than the sun by unit of
mass and time. This staggering bioenergetic cost serves mostly synaptic transmission and …

Mitochondria are subcontractors dedicated to energy production within cells. In human
mitochondria, almost all mitochondrial proteins originate from the nucleus, except for 13 …

Circulating cell-free mitochondrial DNA (ccf-mtDNA) acts as a damage-associated molecular
pattern molecule and may be cargo within extracellular vesicles (EVs). ccf-mtDNA and select …

Whole genome sequencing (WGS) from large clinically unselected cohorts provides a
unique opportunity to assess the penetrance and expressivity of rare and/or known …

Understanding the contributions of mitochondrial genetics to disease pathogenesis is
facilitated by a new and unique model—the mitochondrial-nuclear exchange mouse. Here …