Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

During the last years, studies investigating the intriguing association between
immunodeficiency and autoimmunity led to the discovery of new monogenic disorders, the …

Dysregulation of the alternative complement pathway predisposes individuals to a number
of diseases. It can either be evoked by genetic alterations in or by stabilizing antibodies to …

The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

Hematopoietic and immune cells originate from a common hematopoietic/lymphopoietic
stem cell what explains that these different cell types often share the same receptors and …

The resolution of inflammation is a temporally and spatially coordinated process that in its
innate manifestations, primarily involves neutrophils and macrophages. The shutdown of …

The human complement system constitutes a Janus-faced part of our immune machinery,
which confers rapid protection against microbial intruders but can quickly turn against the …

Complement not only plays a key role in host microbial defense but also modulates the
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …

Eculizumab is a C5 inhibitor approved for the treatment of paroxysmal nocturnal
hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and anti-acetylcholine …