Complement testing in the clinical laboratory

MAV Willrich, KMP Braun, AM Moyer… - Critical reviews in …, 2021 - Taylor & Francis
The complement system is the human's first line of defense against microbial pathogens
because of its important housekeeping and infection/inflammation roles. It is composed of a …

Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases

E Willems, L Lorés‐Motta, A Zanichelli… - Clinical & …, 2020 - Wiley Online Library
Objectives Complement deficiencies are difficult to diagnose because of the variability of
symptoms and the complexity of the diagnostic process. Here, we applied a novel …

Proteomics Analysis in Japanese Medaka Oryzias latipes Exposed to Humic Acid Revealed Suppression of Innate Immunity and Coagulation Proteins

VV Yurchenko, AA Morozov, BA Kiriukhin - Biology, 2022 - mdpi.com
Simple Summary Humic acids are one of the main components of the natural organic matter
in surface waters that give them brown color. These compounds are known to have positive …

Terminal complement pathway deficiency in an adult patient with meningococcal sepsis

F Staels, W Meersseman, P Stordeur… - Case Reports in …, 2022 - Wiley Online Library
The complement system is an essential part of our innate immune system. Three enzymatic
activation pathways are described, all converging into a common terminal pathway which …

Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease

R Hevey, RB Pouw, C Harris… - British journal of …, 2021 - Wiley Online Library
The complement system plays a major role in threat recognition and in orchestrating
responses to microbial intruders and accumulating debris. This immune surveillance is …

PIGW‐related glycosylphosphatidylinositol deficiency: Description of a new patient and review of the literature

A Peron, M Iascone, E Salvatici… - American Journal of …, 2020 - Wiley Online Library
Inherited glycosylphosphatidylinositol (GPI) deficiencies are a group of clinically and
genetically heterogeneous conditions belonging to the congenital disorders of glycosylation …

Structural Characterization and Anticomplement Activity of an Acidic Heteropolysaccharide from Lysimachia christinae Hance

Z Hong, LS Zhou, ZZ Zhao, GQ Yuan, XJ Wang… - Planta …, 2023 - thieme-connect.com
A novel acidic heteropolysaccharide (LCP-90-1) was isolated and purified from a traditional
“heat-clearing” Chinese medicine, Lysimachia christinae Hance. LCP-90-1 (Mw, 20.65 kDa) …

[HTML][HTML] Complement Deficiency

F Mollah, S Tam - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Objectives: Identify the etiology of complement deficiency. Outline the appropriate evaluation
of complement deficiency. Review the management options available for complement …

Polysaccharides Extracted From Panax Ginseng CA Mey Enhance Complement Component 4 Biosynthesis in Human Hepatocytes

S Liu, F Liu, T Wang, J Liu, C Hu, L Sun… - Frontiers in …, 2021 - frontiersin.org
Panax ginseng CA Mey (ginseng) is a classic medicinal plant which is well known for
enhancing immune capacity. Polysaccharides are one of the main active components of …

Novel pathogenic mutations identified in the first Chinese pedigree of complete C6 deficiency

PH Li, WWY Wong, ENY Leung… - Clinical & Translational …, 2020 - Wiley Online Library
Abstract Objectives Complete C6 deficiency (C6Q0) is a rare primary immunodeficiency
leading to increased susceptibility to recurrent Neisseria infections. Patients with C6Q0 have …