Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

Vascular calcification is a common pathologic condition in patients with chronic kidney
disease (CKD) and aging individuals. It has been established that vascular calcification is a …

Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …

The mechanistic target of rapamycin (mTOR) integrates several intracellular and
extracellular signals involved in the regulation of anabolic and catabolic processes. mTOR …

Background Acute kidney injury (AKI) is still a critical problem in clinical practice, with a
heavy burden for national health system around the world. It is notable that sepsis is the …

Cardiovascular diseases (CVDs) are the primary drivers of the growing public health
epidemic and the leading cause of premature mortality and economic burden worldwide …

Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms.
The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction …

Vascular remodelling is an adaptive response to physiological and pathological stimuli that
leads to structural and functional changes in the vascular intima, media, and adventitia …

Background Previous studies have shown that curcumin derivatives can improve the fatty
degeneration of liver tissue that occurs in nonalcoholic fatty liver disease (NAFLD) …