Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

Abstract Background Deregulation of Wnt/β-catenin signaling is a hallmark of the majority of
sporadic forms of colorectal cancer and results in increased stability of the protein β-catenin …

Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …

Azacytidine-and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor
suppressor genes silenced by promoter methylation has provided an alternate approach in …

While specific genes are hypermethylated in the genome of cancer cells, overall
methylcytosine content is often decreased as a consequence of hypomethylation affecting …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

For several decades, we have known that epigenetic regulation is disrupted in cancer.
Recently, an increasing body of data suggests epigenetics might be an intersection of …

Aberrations in DNA methylation patterns have been reported to be involved in driving
changes in the expression of numerous genes during carcinogenesis and have become …

Hepatocellular carcinoma (HCC) is one of the most deadly cancers. Aberrant oncogenic
activation of the Wnt/β-catenin signaling pathway contributes to hepatocellular …