[HTML][HTML] Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

S Salvioli, MS Basile, L Bencivenga, S Carrino… - Ageing Research …, 2023 - Elsevier
According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Alzheimer's disorder: epigenetic connection and associated risk factors

VK Sharma, V Mehta, TG Singh - Current neuropharmacology, 2020 - ingentaconnect.com
The gene based therapeutics and drug targets have shown incredible and appreciable
advances in alleviating human sufferings and complexities. Epigenetics simply means …

Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …

Machine learning to detect Alzheimer's disease from circulating non-coding RNAs

N Ludwig, T Fehlmann, F Kern, M Gogol… - Genomics …, 2019 - academic.oup.com
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-
based diagnostic tests. Often, high-throughput approaches are applied to discover …

Role of epigenetics in Alzheimer's disease pathogenesis

A Stoccoro, F Coppedè - Neurodegenerative disease management, 2018 - Taylor & Francis
Advances in molecular biology technologies have allowed uncovering the role of epigenetic
regulation in several complex diseases, such as cancer and neurodegenerative disorders …

Functional foods: an approach to modulate molecular mechanisms of Alzheimer's disease

A Atlante, G Amadoro, A Bobba, V Latina - Cells, 2020 - mdpi.com
A new epoch is emerging with intense research on nutraceuticals, ie,“food or food product
that provides medical or health benefits including the prevention and treatment of diseases” …

Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer's disease

T C. Silva, JI Young, L Zhang, L Gomez… - Nature …, 2022 - nature.com
To better understand DNA methylation in Alzheimer's disease (AD) from both mechanistic
and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA …

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

A Vasanthakumar, JW Davis, K Idler, JF Waring… - Clinical …, 2020 - Springer
Background Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease
impacting an estimated 44 million adults worldwide. The causal pathology of AD …

Phenotypic heterogeneity in dementia: a challenge for epidemiology and biomarker studies

J Ryan, P Fransquet, J Wrigglesworth… - Frontiers in public …, 2018 - frontiersin.org
Dementia can result from a number of distinct diseases with differing etiology and
pathophysiology. Even within the same disease, there is considerable phenotypic …

Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease

PD Fransquet, J Ryan - Clinical Biochemistry, 2018 - Elsevier
As the prevalence of Alzheimer's disease (AD) increases, the search for a definitive, easy to
access diagnostic biomarker has become increasingly important. Micro RNA (miRNA) …