Background The global population of older individuals is growing, and ageing is a key risk
factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells …

Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Abstract Background and aim The Systemic Immune-Inflammation Index (SII) is a novel
index of inflammation assessment that appears to be superior to the common single blood …

Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality
worldwide and include a group of disorders varying from vasculature, myocardium …

Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes
of mortality and disability in developed countries. Atherosclerotic internal carotid artery …

Extracellular vesicles (EVs), including exosomes and microvesicles, are released by
numerous cell types. EVs are now acknowledged as playing a critical role in cell–cell …

Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular
matrix and orchestrates a damage response to maintain cardiac architecture and …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Background Osteoarthritis (OA) is the most common degenerative disease in joints among
elderly patients. Senescence is deeply involved in the pathogenesis of osteoarthritis …

Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and
contributes to an increased risk of cardiovascular morbidity and mortality. However, effective …