DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …

Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The past decade has revealed the diversity and ubiquity of archaea in nature, with a growing
number of studies highlighting their importance in ecology, biotechnology and even human …

In this hypothesis article, we explore the origin of the eukaryotic nucleus. In doing so, we first
look afresh at the nature of this defining feature of the eukaryotic cell and its core functions …

Thermoacidophilic archaea belonging to the order Sulfolobales thrive in extreme biotopes,
such as sulfuric hot springs and ore deposits. These microorganisms have been model …

Compared with the extensive knowledge on cell division in model eukaryotes and bacteria,
little is known about how archaea divide. Interestingly, both endosomal sorting complex …

In all organisms, the DNA sequence and the structural organization of chromosomes affect
gene expression. The extremely thermophilic crenarchaeon Sulfolobus has one circular …

Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is
shared among the three domains of life and is facilitated by their dual polymerase and …

This review summarizes current knowledge about the mechanisms of timely binding and
dissociation of two nucleoid proteins, IHF and Fis, which play fundamental roles in the …

Since first identified as a separate domain of life in the 1970s, it has become clear that
archaea differ profoundly from both eukaryotes and bacteria. In this review, we look across …